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Michael Ray Irwin, MD

Cousins Center for Psychoneuroimmunology at UCLA
Medical Plaza 300, Room 3109
Los Angeles, CA 90095-7076
Phone: (310) 825-8281
E-mail: mirwin1@ucla.edu

Professor, Semel Institute for Neuroscience & Human Behavior at UCLA

Residency in Psychiatry, University of California, Los Angeles, 1982 – 1985
Internship in Medicine, University of California, San Diego, 1981 – 1982
MD, University of California, San Diego, 1981
BA in Biophysics, University of Pennsylvania, 1976

President-Elect, American Psychosomatic Society, 2010
Lauda Wellness Award, 2009
Secretary Treasurer, American Psychosomatic Society, 2008 – 2010
Distinguished Fellow, American Psychiatric Association, 2008
Chair, Blue Ribbon Intramural Research Strategic Planning Panel, NCCAM, 2008
Norman Cousins Research Award, Psychoneuroimmunology Research Society, 2007
Outstanding Faculty Research Mentor Award, David Geffen School of Medicine at UCLA, 2005
President, Academy of Behavioral Medicine Research, 2003
National Advisory Council Member, Center for Complementary & Alternative Medicine, 2001 – 2004
President, Psychoneuroimmunology Research Society, 2001
Early Career Award, American Psychosomatic Society, 1991

Interactions between behavior and immunity, with an emphasis on the relationships between depression, sleep disturbance, and inflammation.
Longitudinal studies examining the prospective relationships between depression, sleep disturbance,and proinflammatory cytokine activity.
Naturalistic and experimental approaches the impact of sleep loss on the inflammatory signaling pathways and gene expression.

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Motivala SJ, Sarfatti A, Olmos L, Irwin MR: Inflammatory markers and sleep disturbance in major depression. Psychosom Med 76:107-194, 2005Publication #2:

Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole SW: Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med 166:1756-1762, 2006.

Irwin MR, Olmstead R, Motivala SJ: Improving sleep quality in healthy older adults: a randomized controlled trial of Tai Chi vs. education. Sleep 31:1001-8, 2008.

Irwin MR, Wang M, Ribeiro, Cho HJ, Olmstead R, Breen EC, Martinez-Maza O, Cole S: Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 64:538-402, 2008.

Cho J, Lavretsky H, Olmstead R, Oxman MO, Levin MJ, Irwin MR: Poor sleep quality and risk of depression in community-dwelling older adults: a prospective study. Am J Psychiatry 165:1543-1550, 2008.

Collado-Hidalgo A, Bower JE, Ganz P, Irwin MR, Cole SW: Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings. Brain Behav Immun 22:1197-2000, 2008.

Davis MC, Zautra AJ, Younger J, Motivala SJ, Attrep J, Irwin MR: Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue. Brain Behavior and Immunity 22:24-32, 2008.

O'Connor MF, Bower JE, Cho HJ, Creswell JD, Dimitrov S, Hamby ME, Hoyt MA, Martin JL, Robles TF, Sloan EK, Thomas K, Irwin MR: To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain, Behav Immun 23:887-97, 2009.

Cho HJ, Seeman TE, Bower JE, Kiefe CI, Irwin MR: Association between C-Reactive Protein and fatigue five years later -the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Biol Psychiatry 66:871-8, 2009.

Eisenberger NI, Inagaki TK, Rameson L, Mashal N, Irwin MR: An fMRI Study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 47:881-90, 2009.

Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms

Sleep and Immune Mechanisms in Rheumatoid Arthritis

Inflammatory Biology Core (IBC)

Aging: Cytokine Mechanisms and Treatment of Insomnia

Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in Aging

NIH/NIDA — Pain, Opioids and Pro-Inflammatory Immune Responses. (R21 DA 027558; PI: Commton)