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Jorge R. Barrio, PhD

David Geffen School of Medicine at UCLA
Department of Molecular and Medical Pharmacology
10833 Le Conte Avenue, B2-086 CHS
Phone: (310) 825-4167
E-mail: jbarrio@mednet.ucla.edu

Professor, Department of Molecular and Medical Pharmacology

PhD in Biochemistry, University of Buenos Aires PhD in Chemistry, University of Illinois at Urbana-Champaign

In-vivo Probes for Gene Expression, Dopaminergic Mechanisms and Alzheimer Disease: Our program on the development of biological probes is focused on the design, synthesis and validation of positron-emitting and fluorescent labeled probes for enzyme localization and function, presynaptic neurotransmission, postsynaptic receptor interactions, b-amyloid deposition and gene expression. Our investigations have three general aims: Development of biological probes (i.e. radiolabeled fluorinated amino acids, presynaptic dopamine transporter ligand probes) to establish the structural requirements for probing central dopaminergic mechanisms with positron emission tomography (PET). The design of PET reporter probes in the development of in-vivo non-invasive procedures to quantitate gene expression in animals and humans. Probes for glucose transporters (GLUT-1), dopamine-D2 receptors, aromatic amino acid decarboxylase and thymidine kinase are currently being investigated. The development of specific in-vivo probes for b-amyloid plaques for early, non-invasive detection of Alzheimer's disease.

Click here to view publications on PubMed.gov

Michael J. Fox Foundation — Utility of the Amyloid ligand [F-18]FDDNP in Human PET Imaging in Parkinson's Disease. (PI: Y. Bordelon)