UCLA Older Americans Independence Center (OAIC) and
UCLA Clinical and Translational Science Institute (CTSI)
Rapid Pilot Grants Program - Research Funding Available - October 2013
The UCLA OAIC and the UCLA CTSI are soliciting applications for the Rapid Pilot Grants Program for aging-related basic, clinical and health services research. Award size will range from $1,000 to $10,000, dependent on scope of work.
The Principal Investigator (PI) must be a UCLA junior faculty member or advanced trainee, collaborating with a senior UCLA faculty member. A “rolling applications process” will be used. Applications will be accepted until the allocated funds for this program have been spent.
• The PI must be a UCLA junior faculty member or advanced trainee at the post-doctoral level (pre-doctoral students are not eligible) with an identified UCLA faculty mentor (the mentor will be the PI of record and responsible for the project).
• There must be an identified and committed senior mentor at UCLA.
• Because this award will provide limited, targeted support for a discrete need, junior faculty and their mentors must provide tangible evidence that the infrastructural environment to conduct the research will be provided.
- Proposed work must be responsive to the UCLA OAIC research theme (see next page). Applications that are not directly responsive to the mission will not be reviewed.
- Work must advance the independent research goals of the junior investigator.
- Results must have high likelihood of resulting in preliminary data for a larger research grant application and/or first-authored publication by the junior investigator.
- Applications that are aimed at collecting additional preliminary data in response to a recent, favorably scored, but not funded grant application are of particular interest.
- If the rapid pilot entails the study of human or animal subjects, an active IRB or IACUC approval must be in place at the time of the submission of the pilot application.
- Requested funding amount must be appropriate for the proposed work.
- Funds must be expended by June 30, 2014.
UCLA Claude D. Pepper Older Americans Independence Center
The UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to maintain and restore the independence of older persons. The UCLA Center’s theme is “Preventing Disease and Disability in Vulnerable Populations: a Translational Approach”.
We define vulnerable populations as 1) underserved (i.e., low income, uninsured, and minorities) or 2) at increased risk of losing independence because of chronic diseases or conditions, advanced age, or functional impairment. We define translational as overcoming two barriers to effective research. The first is the inability to transfer new understandings of disease mechanisms gained in the laboratory into new diagnostic, therapeutic, and preventive care. The second is the inability to get results from clinical studies into everyday clinical practice and health decision making. In studying vulnerable populations, the UCLA OAIC emphasizes research that extends across the full spectrum of translational research. Within this theme, an important focus of the UCLA OAIC is on understanding the role of inflammation in disease and disability.
The UCLA OAIC addresses health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep disorders, depression), 2) lack of effective preventive or therapeutic approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g., cultural barriers, ineffective health systems). It also helps overcome the barriers between the promise of basic science research and the delivery of better health.
The Center stimulates scientific discovery through 4 Resource Cores (Recruitment and Retention, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies Core, a Research Career Development Core, and a Leadership/Administrative Core.
The UCLA OAIC specific aims are:
- To provide intellectual leadership for research on the Center’s theme, Preventing Disease and Disability in Vulnerable Populations
- To stimulate T1 and T2 translational research addressing the Center’s theme by consultation, provision of services, and collaboration through 4 resource cores
- To engage the Los Angeles community in the conduct of OAIC research
- To foster career development of future research leaders through Career Development Awards
- To nurture novel ideas by funding rapid pilot awards
- To collaborate with other NIH-funded (e.g., CTSI, RCMAR, L.A. CAPRA, Demography Center) and foundation-funded (e.g., Hartford Center of Excellence) efforts that support the UCLA OAIC’s mission
RAPID GRANT APPLICATION PROCESS
Submit an application packet via e-mail to Lucio Arruda. Note that awards will be made on an ongoing basis until program funds are exhausted. Interested applicants should contact Lucio Arruda before submitting to ensure that funds are still available (please see contact information below).
The application packet must include the following:
A 3-page application, single spaced using Arial font 11-point typeface, with one-inch margins, which includes the following:
- Relevance: explicit statement about responsiveness of the research to OAIC theme
- Primary research questions and hypotheses
- Brief background and significance
- Brief methods including discussion of sample size
- Timeline (note expenditure deadline)
- Specific statement about how data will result in one or more of the following: a revised grant application; a new grant application; a manuscript
- Proposed use of pilot funding (~5 sentences describing the amount of funding requested, the exact intended use of the funds, and why this funding is instrumental to the success of the project)
- Biosketches and the NIH Commons User Name of all Investigators;
- IRB or Animal Use approval numbers as appropriate (because of the rapid turnaround time, proposals that require IRB or Animal Use approval must have this approval at the time of application.
- Mentor’s letter that includes explicit description of the infrastructural support that will be available to the pilot project and the nature and amount of mentorship that will be provided.
- For applications that are attempting to collect additional preliminary data in response to recent grant application reviews: include a complete copy of the grant application review and specifically identify the critique that will be addressed by the proposed work.
Funding decisions will be make within 4 weeks of receipt. Successful applicants must agree to submit progress reports, present their findings at local Pepper Center meetings, and cite the UCLA Pepper Center and the UCLA CTSI on all publications related to the support.
The application packet should be e-mailed to the attention of:
UCLA Division of Geriatrics
The UCLA Clinical and Translational Science Institute (CTSI)
The UCLA Clinical and Translational Science Institute (UCLA CTSI) is co-sponsoring the UCLA-OAIC rapid pilot program. A brief description of the UCLA-CTSI follows. Please note that the successful UCLA OAIC-CTSI rapid pilot applicant must be responsive to the UCLA OAIC research mission, described above.
The UCLA Clinical and Translational Science Institute (UCLA CTSI) provides the infrastructure to bring UCLA innovations and resources to bear on the greatest health needs of Los Angeles and the nation. It is a dynamic partnership among UCLA Westwood, Charles Drew University of Medicine and Science, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, the Burns and Allen Research Institute at Cedars-Sinai Medical Center and our Los Angeles community. It is one of 60 NIH-funded CTSIs nationwide.
The UCLA CTSI is organized into nine program areas, which are briefly described below. These program areas are the vehicles through which it CTSI achieves its five main goals: (1) create an academic home for clinical and translational science; (2) build transdisciplinary research teams to accelerate and translate discovery; (3) build and expands strong bi-directional academic-community partnerships; (4) transform educational and career development programs to promote the next generation of clinician investigators and translational scientists; and (5) serve as a national resource for collaborative research.
Pilot and Collaborative Translational and Clinical Studies Program (Pilot/ Collaborative Program) drives research within the UCLA CTSI. It assembles new transdisciplinary teams among senior and junior investigators; provides seed funding; fosters collaborations among basic, clinical and community researchers; provides funding for development of novel methodologies and assists the transition of research from preclinical to Phase I clinical trials; recruits new translational faculty.
Community Engagement in Research Program (CERP) is the primary link to our diverse Los Angeles community. It strengthens and builds strong bi-directional partnerships that help CTSI scientists identify research relevant to community needs. CERP builds community capacity to engage in research; communicates research findings; serves as a point of contact for community health care providers and facilitates opportunities for health services and comparative effectiveness research.
Center for Translational Technologies (CTT) links scientific teams with core technologies. It provides online access to and supervises the use of a diverse array of existing cores; supports development of new technologies; provides personalized counseling to help investigators select and use cores; and facilitates multidisciplinary collaborations and networking.
Clinical and Community Research Resources Program (CCRR) supports and supervises human studies and clinical trials. It builds on our highly successful GCRCs to include flexible, mobile research units that bring scientific teams to our population. It provides bio-nutrition services, clinical research management, and clinical education and training opportunities.
Regulatory Support and Ethics Research ensures that our research is in full regulatory compliance and meets the highest quality assurance standards. It actively seeks and encourages industry alliances and offers ethics counseling and research.
Biomedical Informatics Program (BIP) leverages our expertise and resources in data management to provide databases, tools, resources and infrastructure for the acquisition, storage and analysis of data. It provides the online infrastructure and support for the Office of Investigator Services.
Biostatistics and Computational Biology (BCB) leverages our existing strengths and resources to provide one-stop biostatistical design and data management services to CTSI research teams. It fosters development of novel clinical trial designs and biostatistical methodologies; operates a secure, user-friendly CDM system; and offers expanded translational science courses in clinical trials methodology and new methods in biostatistics and modeling.
Research Education, Training and Career Development (CTSI-ED) houses most of our education and training activities. It builds on collaborations with other CTSI programs to identify training and education needs and opportunities. It ensures CTSI trainees acquire the core competencies needed to conduct multidisciplinary research, and to integrate community priorities and input into research across the translational spectrum.
Evaluation & Tracking (E/T) helps CTSI leaders set goals, measure outcomes, inform leadership decision-making, and identify opportunities for improvement. It conducts studies to improve the science of evaluations, and collaborates with other CTSI researchers to evaluate strategies to boost the speed and efficiency of translation.